The scientific research on Kambo started in et 1980’s. Nobel price nominee Vittorio Erspamer, scientist of the university in Rome, wrote that this secrete contains “a fantastic chemical cocktail with potential medicinal applications, unequalled by any other amphibian”. “Among dozens of peptides found in kambo, up to 7% are bio–active” – From “Making Magic” OMNI 1993
Many of the peptides in kambo are bio–active and work as neurotransmitters, as they bind with receptor sites in the brain triggering chemical reactions in the human body. Kambo is therefore regarded as one of the potent, naturally occurring antibiotics and pain killers discovered so far. 
The peptides found by Erspamer cause many beneficial reactions. Phyllomedusin and phyllokinin are two of them and they both expand the arteries and heighten permeability in the blood-brain barrier, so that other peptides can travel safely through the body’s complex elimination system. This enables kambo to reach places unreachable for other substances. These peptides have also anti-fungal and antimicrobial attributes. 
Bradykins is another group of peptides which has shown to be of interest in battling inflammatory pain. One of the most interesting groups is called dermaseptins, which protect against and attack opportunistic organisms that can follow immune deficiency. Several years of research at the university in Paris has shown that the peptides Dermaseptin B2 and B3 are effective in the extermination of some types of cancer cells.   
As a testament to their medicinal attributes, there are now over 70 kambo related patents. Research on kambo is now being conducted with regards to depression, migraine, circulatory problems, cancer, organ disease, skin and eye issues, fertility issues, HIV/AIDS, hepatitis, brain diseases like Alzheimer’s and Parkinson’s.
Please note that there are no clinical reports confirming that the peptides in kambo are effective in healing the above conditions. We have many anecdotes and observations of kambo helping people heal, but we refrain from making medicinal claims until they are backed by science.
The main families of bioactive peptides identified in the Kambo secretion so far include:
Phyllomedusin – such as tachykinins (which also act as neuropeptides) – produce contraction at the smooth muscle level and increase secretions of the entire gastrointestinal tract such as the salivary glands, stomach, small and large intestine, pancreas and gallbladder. These are the main parts responsible for the deep purge produced by the administration of Kambo.
Phyllokinin and Phyllomedusins – both are potent vasodilators, increasing the permeability of the blood-brain barrier both for their own access as well as for that of other active peptides. Within this family are the medusins, which also have antimicrobial and antifungal properties.
Caeruleins and Sauvagines – They are peptides with chains of 40 amino acids with myotropic properties on the smooth muscles, producing a contraction of the colon and urinary bladder. They produce a drop in blood pressure accompanied by tachycardia. They stimulate the adrenal cortex and pituitary gland, contributing to greater sensory perception and increased resistance. Both peptides possess a great analgesic power, contributing to the increase of physical strength, the capacity to confront physical pain, stress, disease and diminish the symptoms of fatigue. In the medical field this family of peptides contributes to improved digestion and has analgesic properties against pain in renal colic, pain due to peripheral vascular insufficiency and tumour pain.
Dermorphin and deltorphin – These are small peptides composed of 7 amino acids. They are selective agonists of the opiate delta receptors, 4000 times more potent than morphine and 40 times more than the endogenous endorphins.
Adenoregulins – discovered in the 90s by John Daly’s team at the National Institute of Health in the United States. Adenoregulin works on the human body through the adenosine receptors, a fundamental component throughout all human cellular fuel. These receptors may offer a target for the treatment of depression, stroke and cognitive loss diseases, such as Alzheimer’s disease and also Parkinson’s.
Antimicrobial peptides: Dermaseptins, including adenoregulins (with 33 amino acids), plasticins and philloseptins form part of a family of a broad spectrum of antimicrobial peptides involved in the defence of frogs’ bare skin against microbial invasion. These are the first vertebrate peptides that show lethal effects against filamentous fungi responsible for severe opportunistic infections which accompany the immunodeficiency syndrome and the use of immunosuppressive agents. They also show lethal effects against a broad spectrum of bacteria both large+ and large-, fungi, yeasts and protozoa. Several years of research carried out at the University of Paris have shown that peptides Dermaseptin B2 and B3 are effective in killing certain types of cancer cells. Research at Queens University in Belfast recently won a prestigious award for his ground-breaking work with cancer and Kambo. Its action mechanism is produced by inhibiting the angiogenesis of tumour cells, with selective cytotoxicity for these cells.
Bradykinins – such as phyllokinins and tryptophilins. They are peptides with structure and properties similar to human bradykinin. They are important sources of scientific study as they are hypotensive and due to producing vasodilation, contraction of the non-vascular smooth muscle, increase vascular permeability, also related to the mechanism of inflammatory pain.
Bombesins – these peptides stimulate the secretion of hydrochloric acid by acting on the G cells of the stomach, regardless of the pH of the medium. They also increase pancreatic secretion, intestinal myoelectric activity and smooth muscle contractibility.
Ceruleins – Stimulate gastric, bile and pancreatic secretions, and certain smooth muscle. They could be used in the paralytic ileus and as a diagnostic medium in pancreatic dysfunction.
Tryptophilins – are neuropeptides consisting of 4 to 14 amino acids, which are opening up new perspectives on how the human brain works.
(Information about peptide families copied from Rosa Sanchi’s investigation of Kambo, dated 4. August 2017 )
- Kambô: scientific research and healing treatments – Giovanni Lattanzi (17.07.17)
- Medusins: a new class of antimicrobal peptides from the skin secretions of phyllomedusine frogs (24. 11. 2017) https://www.ncbi.nlm.nih.gov/pubmed/23415652
- Phyllomedusa bicolor skin secretion and the kambô ritual (24. 11. 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582952/
- solation and Structure of Novel Defensive Peptides from Frog Skin (24. 11. 2017) https://www.ncbi.nlm.nih.gov/pubmed/8306981
- Antitumor and angiostatic activities of the antimicrobal peptide dermaseptin B2 (24. 11. 2017) https://www.ncbi.nlm.nih.gov/pubmed/23028527
- Antitumor and angiostatic peptides from frog secretions (24. 11. 2017) https://www.ncbi.nlm.nih.gov/pubmed/21132338
- INVESTIGATING THE HEALING POWER OF KAMBO. The solution to so many human malaises comes from the frogs of the Amazon. (24. 11. 2017) http://www.albertojosevarela.com/en/investigating-the-healing-power-of-kambo-the-solution-to-so-many-human-malaises-comes-from-the-frogs-of-the-amazon/